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Published in 2022 at "ESC Heart Failure"
DOI: 10.1002/ehf2.14264
Abstract: The progression of atherosclerosis can lead to the occurrence of multiple cardiovascular diseases (coronary heart disease, etc.). E prostanoid receptor‐3 (EP3) is known to participate in the progression of atherosclerosis. This study aimed to investigate…
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Keywords:
promotes oxidized;
prostanoid receptor;
receptor promotes;
low density ... See more keywords
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Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28928
Abstract: Prostaglandin E2 (PGE2) is an important lipid mediator of inflammation. However, whether and how PGE2 regulates hepatic cholesterol metabolism remains unknown. We found that expression of the PGE2 receptor, E prostanoid receptor 3 (EP3) expression…
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Keywords:
prostanoid receptor;
cholesterol;
mice;
receptor ... See more keywords
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Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.08.012
Abstract: Abstract Prostaglandin (PG) D2, a prostanoid known to have hypotensive effect, can evoke increased in vitro prepartum myometrial contraction resulting from up‐regulation of the F prostanoid (FP) receptor. The present study further determined postpartum rat…
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Keywords:
uterine contraction;
prostanoid receptor;
prepartum;
postpartum ... See more keywords
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Published in 2021 at "Nature Cell Biology"
DOI: 10.1038/s41556-021-00708-8
Abstract: Inflammatory bowel diseases present with elevated levels of intestinal epithelial cell (IEC) death, which compromises the gut barrier, activating immune cells and triggering more IEC death. The endogenous signals that prevent IEC death and break…
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Keywords:
prostanoid receptor;
resolution intestinal;
intestinal inflammation;
necroptosis ... See more keywords
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Published in 2018 at "Nature Chemical Biology"
DOI: 10.1038/s41589-018-0171-8
Abstract: Prostanoids are a series of bioactive lipid metabolites that function in an autacoid manner via activation of cognate G-protein-coupled receptors (GPCRs). Here, we report the crystal structure of human prostaglandin (PG) E receptor subtype EP3…
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Keywords:
prostanoid receptor;
crystal structure;
receptor ep3;
endogenous agonist ... See more keywords
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Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-09288-w
Abstract: This study aimed to determine whether E prostanoid receptor-3 (EP3) is involved in prostacyclin (PGI2)-evoked vasoconstrictor activity of resistance arteries and if so, how it changes under hypertensive conditions. Mesenteric resistance arteries from Wistar-Kyoto rats…
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Keywords:
mesenteric resistance;
prostanoid receptor;
activity;
resistance arteries ... See more keywords
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Published in 2017 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201606987
Abstract: Niacin, as an antidyslipidemic drug, elicits a strong flushing response by release of prostaglandin (PG) D2. However, whether niacin is beneficial for inflammatory bowel disease (IBD) remains unclear. Here, we observed niacin administration‐enhanced PGD2 production…
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Keywords:
prostanoid receptor;
prostaglandin;
tnbs induced;
colitis ... See more keywords
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Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00781
Abstract: We investigated the effects of prostaglandin E2 (PGE2), an important inflammatory lipid mediator, on the cytotoxicity–genotoxicity induced by arsenite. With the use of a toxicity paradigm in which the metalloid uniquely induces mitochondrial superoxide (mitoO2…
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Keywords:
prostanoid receptor;
induced arsenite;
mitochondrial superoxide;
formation ... See more keywords