Association of the Placement of a Perirectal Hydrogel Spacer With the Clinical Outcomes of Men Receiving Radiotherapy for Prostate Cancer: A Systematic Review and Meta-analysis.
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DOI: 10.1001/jamanetworkopen.2020.8221
Abstract: Importance Perirectal spacers are intended to lower the risk of rectal toxic effects associated with prostate radiotherapy. A quantitative synthesis of typical clinical results with specific perirectal spacers is limited. Objective To evaluate the association… read more here.
Keywords: prostate; spacer; radiotherapy; group ... See more keywords
Association of the USPSTF Grade D Recommendation Against Prostate-Specific Antigen Screening With Prostate Cancer–Specific Mortality
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DOI: 10.1001/jamanetworkopen.2022.11869
Abstract: Key Points Question Was the 2012 US Preventive Services Task Force (USPSTF) Grade D recommendation against prostate-specific antigen (PSA) screening for all men associated with prostate cancer–specific mortality (PCSM)? Findings This cross-sectional study found statistically… read more here.
Keywords: uspstf grade; recommendation; prostate; grade recommendation ... See more keywords
Striking the Right Balance With Prostate Cancer Screening.
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DOI: 10.1001/jamanetworkopen.2022.2174
Abstract: Desai and colleagues,1 analyzing Surveillance, Epidemiology, and End Results data from 2004 through 2018, found significantly increasing incidence rates of metastatic prostate cancer (mPCa) among men aged 45 to 74 years (during the period 2010-2018)… read more here.
Keywords: recommendation; incidence; prostate; pca ... See more keywords
Risk of Tumor Upstaging With Prostate-Specific Membrane Antigen Positron Emission Tomography in Patients With High-Risk Prostate Cancer
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DOI: 10.1001/jamanetworkopen.2022.31101
Abstract: This cross-sectional study of data from the National Comprehensive Cancer Network assesses the association of prostate-specific membrane antigen positron emission tomography with tumor upstaging risk in patients with high-risk prostate cancer. read more here.
Keywords: prostate specific; prostate; membrane antigen; specific membrane ... See more keywords
Association Between Combined TMPRSS2: ERG and PCA3 RNA Urinary Testing and Detection of Aggressive Prostate Cancer
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DOI: 10.1001/jamaoncol.2017.0177
Abstract: Importance Potential survival benefits from treating aggressive (Gleason score, ≥7) early-stage prostate cancer are undermined by harms from unnecessary prostate biopsy and overdiagnosis of indolent disease. Objective To evaluate the a priori primary hypothesis that… read more here.
Keywords: prostate; biopsy; pca3; prostate cancer ... See more keywords
Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography in Locally Advanced, Recurrent, and Metastatic Prostate Cancer.
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DOI: 10.1001/jamaoncol.2017.0287
Abstract: Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography in Locally Advanced, Recurrent, and Metastatic Prostate Cancer To the Editor We read with great interest the recent article by Lindenberg et al.1 We commend the authors on… read more here.
Keywords: psma pet; prostate cancer; prostate; tomography ... See more keywords
Associations of Luminal and Basal Subtyping of Prostate Cancer With Prognosis and Response to Androgen Deprivation Therapy
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DOI: 10.1001/jamaoncol.2017.0751
Abstract: Importance There is a clear need for a molecular subtyping approach in prostate cancer to identify clinically distinct subgroups that benefit from specific therapies. Objectives To identify prostate cancer subtypes based on luminal and basal… read more here.
Keywords: prostate; luminal basal; biology; prostate cancer ... See more keywords
Development and Validation of a Clinical Prognostic Stage Group System for Nonmetastatic Prostate Cancer Using Disease-Specific Mortality Results From the International Staging Collaboration for Cancer of the Prostate.
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DOI: 10.1001/jamaoncol.2020.4922
Abstract: Importance In 2016, the American Joint Committee on Cancer (AJCC) established criteria to evaluate prediction models for staging. No localized prostate cancer models were endorsed by the Precision Medicine Core committee, and 8th edition staging… read more here.
Keywords: prostate; system; validation; prostate cancer ... See more keywords
Association of Prostate-Specific Antigen Screening Rates With Subsequent Metastatic Prostate Cancer Incidence at US Veterans Health Administration Facilities.
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DOI: 10.1001/jamaoncol.2022.4319
Abstract: Importance There is controversy about the benefit of prostate-specific antigen (PSA) screening. Prostate-specific antigen screening rates have decreased since 2008 in the US, and the incidence of metastatic prostate cancer has increased. However, there is… read more here.
Keywords: prostate cancer; prostate; metastatic prostate; screening rates ... See more keywords
Extended Focal Ablation of Localized Prostate Cancer With High-Frequency Irreversible Electroporation: A Nonrandomized Controlled Trial.
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DOI: 10.1001/jamasurg.2022.2230
Abstract: Importance Focal therapy of prostate cancer must balance the oncologic outcome and functional outcome. High-frequency irreversible electroporation (H-FIRE) can destroy cancer cells while selectively preserving surrounding nerves and blood vessels, but no clinical trials have been… read more here.
Keywords: gleason score; prostate cancer; prostate; trial ... See more keywords
Gene expression panel predicts metastatic‐lethal prostate cancer outcomes in men diagnosed with clinically localized prostate cancer
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DOI: 10.1002/1878-0261.12014
Abstract: Prognostic biomarkers are needed to distinguish patients with clinically localized prostate cancer (PCa) who are at high risk of metastatic progression. The tumor transcriptome may reveal its aggressiveness potential and have utility for predicting adverse… read more here.
Keywords: prostate; metastatic lethal; clinically localized; prostate cancer ... See more keywords