Radical Prostatectomy for Locally Advanced Prostate Cancers—Review of Literature
Sign Up to like & getrecommendations! Published in 2017 at "Indian Journal of Surgical Oncology"
DOI: 10.1007/s13193-016-0599-9
Abstract: Twenty-five to thirty percent of patients with prostate cancer present with locally advanced disease. While risk stratification remains the same with high incidence of upstaging of disease on imaging and histopathological evaluation; there have been… read more here.
Keywords: locally advanced; radical prostatectomy; advanced prostate; prostate cancers ... See more keywords
Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06177-2
Abstract: The incidence of aggressive neuroendocrine prostate cancers (NEPC) related to androgen-deprivation therapy (ADT) is rising. NEPC is still poorly understood, such as its neuroendocrine differentiation (NED) and angiogenic phenotypes. Here we reveal that NED and… read more here.
Keywords: prostate; angiogenesis; tsp1; androgen deprivation ... See more keywords
Subcellular Compartmentalization of Survivin is Associated with Biological Aggressiveness and Prognosis in Prostate Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-60064-9
Abstract: The role of subcellular survivin compartmentalization in the biology and prognosis of prostate cancer is unclear. We therefore investigated subcellular localization of survivin in more than 3000 prostate cancer patients by quantitative immunohistochemistry and performed… read more here.
Keywords: prostate; survivin; prostate cancer; biology ... See more keywords
Combination of MRI prostate and 18F‐DCFPyl PSMA PET/CT detects all clinically significant prostate cancers in treatment‐naive patients: An international multicentre retrospective study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Imaging and Radiation Oncology"
DOI: 10.1111/1754-9485.13382
Abstract: Clinical and biochemical assessment and biopsies can miss clinically significant prostate cancers (csPCa) in up to 20% of patients and diagnose clinically insignificant tumours leading to overtreatment. This retrospective study analyses the accuracy of 18F‐DCFPyL… read more here.
Keywords: significant prostate; retrospective study; prostate cancers; prostate ... See more keywords
Inflammatory Cytokine Signaling during Development of Pancreatic and Prostate Cancers
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Immunology Research"
DOI: 10.1155/2017/7979637
Abstract: Inflammation is essential for many diseases including cancer. Activation and recruitment of immune cells during inflammation result in a cytokine- and chemokine-enriched cell environment, which affects cancer development. Since each type of cancer has its… read more here.
Keywords: cytokine signaling; pancreatic prostate; cancer; development ... See more keywords
Detecting MRI-Invisible Prostate Cancers Using a Weakly Supervised Deep Learning Model
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Biomedical Imaging"
DOI: 10.1155/2024/2741986
Abstract: Background MRI is an important tool for accurate detection and targeted biopsy of prostate lesions. However, the imaging appearances of some prostate cancers are similar to those of the surrounding normal tissue on MRI, which… read more here.
Keywords: mri invisible; systematic biopsy; prostate; prostate cancers ... See more keywords
Abstract LB161: Discovery of an oral, potent, and selective CDK9 molecular glue degrader SLX-3065 active in aggressive variant prostate cancers (AVPC)
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-lb161
Abstract: Background: The use of new potent targeted therapies in prostate cancers has led to the resistance and development of highly aggressive variant prostate cancers (AVPC), including neuroendocrine prostate cancers (NEPC). N-MYC and C-MYC oncogenes overexpress… read more here.
Keywords: cdk9; prostate cancers; slx 3065; molecular glue ... See more keywords
Apalutamide OK'd for Some Prostate Cancers.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-nb2018-012
Abstract: The FDA approved the antiandrogen apalutamide for the treatment of men with nonmetastatic, castration-resistant prostate cancer, the first drug for these patients greenlighted by the agency. Data from the definitive trial of apalutamide, presented at… read more here.
Keywords: drug; apalutamide prostate; prostate cancers;
PARP inhibitors in prostate cancers, is it time for combinations?
Sign Up to like & getrecommendations! Published in 2024 at "Therapeutic Advances in Medical Oncology"
DOI: 10.1177/17588359241242959
Abstract: Despite several improvements in outcomes, metastatic prostate cancer remains deadly. Alterations in the homologous recombination repair (HRR) pathway are associated with more aggressive disease. Olaparib and rucaparib, two poly-ADP-ribose polymerase (PARP) inhibitors, have received approval… read more here.
Keywords: oncology; time combinations; inhibitors prostate; prostate cancers ... See more keywords
Genome-wide crosstalk between steroid receptors in breast and prostate cancers
Sign Up to like & getrecommendations! Published in 2021 at "Endocrine-Related Cancer"
DOI: 10.1530/erc-21-0038
Abstract: Steroid receptors (SRs) constitute an important class of signal-dependent transcription factors (TFs). They regulate a variety of key biological processes and are crucial drug targets in many disease states. In particular, estrogen (ER) and androgen… read more here.
Keywords: steroid receptors; breast prostate; prostate; genome wide ... See more keywords
Does uneven geographic distribution of urologists affect bladder and prostate cancers mortality? national health insurance data in korea from 2007 to 2011.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18036
Abstract: The relationship between distribution of urologists and mortality of bladder and prostate cancers has not been clearly established. The aim of this study was to investigate the relationship between uneven distribution of urologists and urologic… read more here.
Keywords: prostate; bladder; bladder prostate; distribution urologists ... See more keywords