Phosphorylated LASS2 inhibits prostate carcinogenesis via negative regulation of Wnt/β‐catenin signaling
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29926
Abstract: LASS2 is a novel tumor‐suppressor gene and has been characterized as a ceramide synthase, which synthesizes very‐long acyl chain ceramides. However, LASS2 function and pathway‐related activity in prostate carcinogenesis are still largely unexplored. Here, we… read more here.
Keywords: inhibits prostate; phosphorylated lass2; catenin; prostate carcinogenesis ... See more keywords
Fibroblast heterogeneity in prostate carcinogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.10.028
Abstract: Our understanding of stromal components, specifically cancer-associated fibroblasts (CAF), in prostate cancer (PCa), has evolved from considering these cells as inert bystanders to acknowledging their significance as players in prostate tumorigenesis. CAF are multifaceted-they promote… read more here.
Keywords: caf; heterogeneity; heterogeneity prostate; fibroblast heterogeneity ... See more keywords
Cycloartane-type sapogenol derivatives inhibit NFκB activation as chemopreventive strategy for inflammation-induced prostate carcinogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Steroids"
DOI: 10.1016/j.steroids.2018.04.005
Abstract: HIGHLIGHTS9,19‐cyclolanostane derivatives starting from cycloastragenol were synthesized.Five analogs were selected to be screened for their anti‐inflammatory properties.The compounds inhibited NF&kgr;B activation.They were shown to be promising anti‐inflammatory agents.The compounds are noteworthy candidates for prostate cancer… read more here.
Keywords: cycloartane type; inflammation; prostate carcinogenesis; inflammation induced ... See more keywords
Prostate carcinogenesis: inflammatory storms
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Cancer"
DOI: 10.1038/s41568-020-0267-9
Abstract: Prostate cancer is a major cause of cancer morbidity and mortality. Intra-prostatic inflammation is a risk factor for prostate carcinogenesis, with diet, chemical injury and an altered microbiome being causally implicated. Intra-prostatic inflammatory cell recruitment… read more here.
Keywords: inflammatory storms; inflammatory; prostate carcinogenesis; cancer ... See more keywords
Abstract A056: AR/FOXA1-mediated active gene repression as a mechanism of prostate carcinogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-a056
Abstract: The identity of the prostate gland is defined by transcription factors (TF) like the androgen receptor (AR), FOXA1, and NKX3.1 that bind regulatory elements early in development to activate the lineage gene program. For instance,… read more here.
Keywords: foxa1; gene repression; prostate carcinogenesis; deptor ... See more keywords
Vitamin D Signaling Suppresses Early Prostate Carcinogenesis in TgAPT121 Mice
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Prevention Research"
DOI: 10.1158/1940-6207.capr-18-0401
Abstract: We tested whether lifelong modification of vitamin D signaling can alter the progression of early prostate carcinogenesis in studies using mice that develop high-grade prostatic intraepithelial neoplasia that is similar to humans. Two tissue-limited models… read more here.
Keywords: mice; early prostate; vitamin; vitamin signaling ... See more keywords
Chemopreventive effect of cinnamon and its bioactive compounds in a rat model of premalignant prostate carcinogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer prevention research"
DOI: 10.1158/1940-6207.capr-22-0327
Abstract: Cinnamon and its bioactive compounds inhibit prostate cancer cell proliferation in vitro. The aim of the present study was to assess the chemopreventive efficacy of cinnamon (CN) and its bioactive compounds in vivo using N-methyl-N-nitrosourea… read more here.
Keywords: cinnamon bioactive; bioactive compounds; prostate carcinogenesis; premalignant prostate ... See more keywords
Connecting the Dots Between the Gut–IGF-1–Prostate Axis: A Role of IGF-1 in Prostate Carcinogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.852382
Abstract: Prostate cancer (PCa) is the most common malignancy in men worldwide, thus developing effective prevention strategies remain a critical challenge. Insulin-like growth factor 1 (IGF-1) is produced mainly in the liver by growth hormone signaling… read more here.
Keywords: prostate; igf prostate; gut igf; pca ... See more keywords
Tracking Prostate Carcinogenesis over Time through Urine Proteome Profiling in an Animal Model: An Exploratory Approach
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147560
Abstract: Prostate cancer (PCa) is one of the most lethal diseases in men, which justifies the search for new diagnostic tools. The aim of the present study was to gain new insights into the progression of… read more here.
Keywords: urine proteome; carcinogenesis time; prostate carcinogenesis; carcinogenesis ... See more keywords