Sox2 is necessary for androgen ablation-induced neuroendocrine differentiation from Pten null Sca-1+ prostate luminal cells
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-01526-2
Abstract: Prostate adenocarcinoma undergoes neuroendocrine differentiation to acquire resistance toward antihormonal therapies. The underlying mechanisms have been investigated extensively, among which Sox2 has been shown to play a critical role. However, genetic evidence in mouse models… read more here.
Keywords: neuroendocrine differentiation; induced neuroendocrine; ablation; prostate luminal ... See more keywords
Abstract A068: Prostate luminal progenitors as the cell-of-origin for androgen receptor-independent prostate cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-a068
Abstract: In the recent years, we have witnessed the emergence of androgen receptor (AR)-independent prostate cancer (AIPC) with the clinical use of second-generation androgen deprivation therapy, namely Enzalutamide and Abiraterone. Unluckily, treatment options for the end-stage… read more here.
Keywords: prostate cancer; independent prostate; androgen receptor; prostate luminal ... See more keywords
Remaining Prostate Luminal Cells Regenerate after Androgen Deprivation.
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DOI: 10.1158/2159-8290.cd-rw2020-068
Abstract: Most prostate luminal cells that survive androgen deprivation can contribute to organ regeneration. read more here.
Keywords: prostate luminal; remaining prostate; androgen deprivation; cells regenerate ... See more keywords