DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-1085-y
Abstract: The DEPTOR-mTORC1/2 axis has been shown to play an important, but a context dependent role in the regulation of proliferation and the survival of various cancer cells in cell culture settings. The in vivo role… read more here.
Keywords: prostate tumorigenesis; tumor suppressor; mtorc1; tumorigenesis via ... See more keywords
OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR
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DOI: 10.1038/s42003-022-03133-1
Abstract: Ovarian tumor (OTU) subfamily deubiquitinases are involved in various cellular processes, such as inflammation, ferroptosis and tumorigenesis; however, their pathological roles in prostate cancer (PCa) remain largely unexplored. In this study, we observed that several… read more here.
Keywords: prostate tumorigenesis; otud6a; brg1; pca ... See more keywords
FAM84B promotes prostate tumorigenesis through a network alteration
Sign Up to like & getrecommendations! Published in 2019 at "Therapeutic Advances in Medical Oncology"
DOI: 10.1177/1758835919846372
Abstract: Background: The aim of this study was to investigate the contributions of FAM84B in prostate tumorigenesis and progression. Methods: A FAM84B mutant with deletion of its HRASLS domain (ΔHRASLS) was constructed. DU145 prostate cancer (PC)… read more here.
Keywords: prostate tumorigenesis; hrasls; network; fam84b ... See more keywords