4 Molecularly guided multiplexed digital spatial analysis reveals differential gene expression profiles in the WNT-β-catenin pathway between melanoma and prostate tumors
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0004
Abstract: Background The canonical WNT-β-catenin signaling pathway is vital for development and tissue homeostasis but becomes strongly tumorigenic when dysregulated. and alter the transcriptional signature of a cell to promote malignant transformation. However, thorough characterization of… read more here.
Keywords: melanoma; prostate tumors; ctnnb1 expression; expression ... See more keywords
Cabozantinib Unlocks Efficient In Vivo Targeted Delivery of Neutrophil-Loaded Nanoparticles into Murine Prostate Tumors
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-20-0167
Abstract: A major barrier to the successful application of nanotechnology for cancer treatment is the suboptimal delivery of therapeutic payloads to metastatic tumor deposits. We previously discovered that cabozantinib, a tyrosine kinase inhibitor, triggers neutrophil-mediated anticancer… read more here.
Keywords: prostate; prostate tumors; bsa nps; delivery ... See more keywords
Niraparib Shrinks BRCA-Mutated Prostate Tumors.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-nb2019-030
Abstract: Niraparib showed promising signs of efficacy in the phase II GALAHAD trial of men with advanced prostate cancer whose tumors harbor mutations in the DNA damage-response pathway, especially among patients with gene defects in BRCA1… read more here.
Keywords: shrinks brca; prostate tumors; mutated prostate; niraparib shrinks ... See more keywords
IL-6 is associated to IGF-1Ec upregulation and Ec peptide secretion, from prostate tumors
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DOI: 10.1186/s10020-018-0003-z
Abstract: BackgroundEc peptide (PEc), resulting from the proteolytic cleavage of the IGF-1Ec isoform, is involved in prostate cancer progression and metastasis, whereas in muscle tissue, it is associated with the mobilization of satellite cells prior to… read more here.
Keywords: igf 1ec; 1ec upregulation; secretion; prostate tumors ... See more keywords
MR-CBCT image-guided system for radiotherapy of orthotopic rat prostate tumors
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DOI: 10.1371/journal.pone.0198065
Abstract: Multi-modality image-guided radiotherapy is the standard of care in contemporary cancer management; however, it is not common in preclinical settings due to both hardware and software limitations. Soft tissue lesions, such as orthotopic prostate tumors,… read more here.
Keywords: radiotherapy; prostate tumors; cbct image; cbct ... See more keywords
Proteomic and Transcriptomic Profiling Reveals Mitochondrial Oxidative Phosphorylation as Therapeutic Vulnerability in Androgen Receptor Pathway Active Prostate Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14071739
Abstract: Simple Summary Metastatic prostate cancer (PC) is the second leading cause of cancer deaths in males. The lack of preclinical models and molecular characterization for advanced stage PC is a key barrier in understanding the… read more here.
Keywords: pathway active; prostate; prostate tumors; cancer ... See more keywords