Molecular Pathology of High-Grade Prostatic Intraepithelial Neoplasia: Challenges and Opportunities.
Sign Up to like & getrecommendations! Published in 2019 at "Cold Spring Harbor perspectives in medicine"
DOI: 10.1101/cshperspect.a030403
Abstract: A better understanding of the early stages of prostate cancer initiation, potentially arising from precursor lesions, may fuel development of powerful approaches for prostate cancer prevention or interception. The best-known candidate for such a precursor… read more here.
Keywords: grade prostatic; high grade; pathology; intraepithelial neoplasia ... See more keywords
Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo2295
Abstract: Prostate cancer (PCa) is a leading cause of cancer-related deaths. The slow evolution of precancerous lesions to malignant tumors provides a broad time frame for preventing PCa. To characterize prostatic intraepithelial neoplasia (PIN) progression, we… read more here.
Keywords: malignant progression; progression; plasticity; intraepithelial neoplasia ... See more keywords
Focal Signet Ring Cell High-Grade Prostatic Intraepithelial Neoplasia on Needle Biopsy
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Surgical Pathology"
DOI: 10.1177/1066896916685835
Abstract: Signet ring cell prostatic intraepithelial neoplasia is a rare speculated variant of high-grade prostatic intraepithelial neoplasia (HGPIN). Here, we present a free-standing and isolated signet ring cell HGPIN that was not associated with invasive carcinoma… read more here.
Keywords: prostatic intraepithelial; intraepithelial neoplasia; signet ring; ring cell ... See more keywords
A basal cell defect promotes budding of prostatic intraepithelial neoplasia
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.188177
Abstract: ABSTRACT Basal cells in a simple secretory epithelium adhere to the extracellular matrix (ECM), providing contextual cues for ordered repopulation of the luminal cell layer. Early high-grade prostatic intraepithelial neoplasia (HG-PIN) tissue has enlarged nuclei… read more here.
Keywords: basal; intraepithelial neoplasia; basal cell; prostatic intraepithelial ... See more keywords
Prostatic intraepithelial neoplasia-like ductal prostatic adenocarcinoma: A case suitable for active surveillance?
Sign Up to like & getrecommendations! Published in 2017 at "Urology Annals"
DOI: 10.4103/0974-7796.198829
Abstract: In contrast to typical prostatic ductal adenocarcinoma, prostatic intraepithelial neoplasia (PIN)-like ductal adenocarcinoma is a rare variant of prostate cancer with low-grade clinical behavior. We report a case of a 66-year-old African-American male with an… read more here.
Keywords: prostate; active surveillance; like ductal; intraepithelial neoplasia ... See more keywords