A Compact and Synthetically Accessible Fluorine‐18 Labelled Cyclooctyne Prosthetic Group for Labelling of Biomolecules by Copper‐Free Click Chemistry
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DOI: 10.1002/cmdc.201800334
Abstract: A new fluorine‐containing azadibenzocyclooctyne (ADIBO‐F) was designed using a synthetically accessible pathway. The fluorine‐18 prosthetic group was prepared from its toluenesulfonate precursor and isolated in 21–35 % radiochemical yield in 30 minutes of synthetic time. ADIBO‐F has… read more here.
Keywords: compact synthetically; prosthetic group; chemistry; synthetically accessible ... See more keywords
Dehydrogenase/reductase activity of human carbonyl reductase 1 with NADP(H) acting as a prosthetic group.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.11.090
Abstract: Carbonyl reductase 1 (CBR1) is an NADP-dependent enzyme that exerts a detoxifying role, which catalyses the transformation of carbonyl-containing compounds. The ability of CBR1 to act on adducts between glutathione and lipid peroxidation derived aldehydes… read more here.
Keywords: reductase; prosthetic group; carbonyl reductase; cbr1 ... See more keywords
Substitution of iron with cobalt in the prosthetic group of bacterial cytochrome P450: Effects on the stability and structure of the protein
Sign Up to like & getrecommendations! Published in 2019 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2018.12.043
Abstract: Abstract The origin of thermostability of the heme monooxygenase from Thermus thermophilus, CYP175A1 has been investigated using multi-wavelength circular dichroism (CD) spectroscopy at different temperatures. The far-UV and visible CD studies were carried out on… read more here.
Keywords: prosthetic group; wtcyp175a1; stability; structure protein ... See more keywords