Design, synthesis, and biological evaluation of potent FAK-degrading PROTACs
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2100886
Abstract: Abstract FAK mediated tumour cell migration, invasion, survival, proliferation and regulation of tumour stem cells through its kinase-dependent enzymatic functions and kinase-independent scaffolding functions. At present, the development of FAK PROTACs has become one of… read more here.
Keywords: design synthesis; synthesis biological; fak; biological evaluation ... See more keywords