A Temporal PROTAC Cocktail‐Mediated Sequential Degradation of AURKA Abrogates Acute Myeloid Leukemia Stem Cells
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DOI: 10.1002/advs.202104823
Abstract: AURKA is a potential kinase target in various malignancies. The kinase‐independent oncogenic functions partially disclose the inadequate efficacy of the kinase inhibitor in a Phase III clinical trial. Simultaneously targeting the catalytic and noncatalytic functions… read more here.
Keywords: protac cocktail; myeloid leukemia; acute myeloid; stem ... See more keywords