Interplay of PROTAC Complex Dynamics for Undruggable Targets: Insights into Ternary Complex Behavior and Linker Design.
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DOI: 10.1021/acsmedchemlett.4c00189
Abstract: Protein degraders, such as bifunctional proteolysis-targeting chimeras (PROTACs), selectively eliminate target proteins by leveraging the natural protein degradation machinery. PROTACs bridge the target protein with an E3 ligase, which induces ubiquitination and degradation. Investigating ternary… read more here.
Keywords: complex dynamics; protac complex; linker; ternary complex ... See more keywords