Discovery of LD-110 as an Effective LSD1 PROTAC Degrader for the Treatment of Esophagus Squamous Cancer
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DOI: 10.1021/acs.jmedchem.5c02246
Abstract: LSD1, a pivotal epigenetic regulator mediating histone demethylation, is an attractive therapeutic target due to its oncogenic roles in cancers. Although numerous small-molecule inhibitors of LSD1 were advanced to clinical trials, only one PROTAC-based degrader… read more here.
Keywords: protac; esophagus squamous; protac degrader; degrader ... See more keywords