Discovery of Coumarin-Based MEK1/2 PROTAC Effective in Human Cancer Cells.
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DOI: 10.1021/acsmedchemlett.2c00446
Abstract: The RAF/MEK/ERK pathway is a crucial signal path which is closely associated with the proliferation, differentiation, and apoptosis of tumors. MEK1/2 is a key kinase target in the pathway, with ERK1/2 acting as the main… read more here.
Keywords: effective human; protac effective; human cancer; mek1 ... See more keywords