Improved Accuracy for Modeling PROTAC-Mediated Ternary Complex Formation and Targeted Protein Degradation via New In Silico Methodologies.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.0c00897
Abstract: Extending upon our previous publication (Drummond, M., Williams, C., In Silico Modeling of PROTAC-mediated Ternary Complexes: Validation and Application, J. Chem. Inf. Model., 2019, 59, 1634-1644), in this work two additional computational methods are presented… read more here.
Keywords: ternary complex; protac mediated; protac; mediated ternary ... See more keywords
Target protein localization and its impact on PROTAC-mediated degradation.
Sign Up to like & getrecommendations! Published in 2022 at "Cell chemical biology"
DOI: 10.2139/ssrn.4006704
Abstract: Proteolysis-targeting chimeras (PROTACs) bring a protein of interest (POI) into spatial proximity of an E3 ubiquitin ligase, promoting POI ubiquitylation and proteasomal degradation. PROTACs rely on endogenous cellular machinery to mediate POI degradation, therefore the… read more here.
Keywords: poi; localization; mediated degradation; degradation ... See more keywords