Protac-mediated degradation of neutrophil elastase as a potential therapeutic strategy for ELANE-related neutropenia
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-620
Abstract: Background: Mutations in ELANE are the most common cause of both cyclic and severe congenital neutropenia. ELANE encodes neutrophil elastase (NE), a tissue-specific serine protease expressed primarily in neutrophils. Expression of the mutant protein impairs… read more here.
Keywords: protac molecules; protac; degradation; mutant ... See more keywords
Recent advancements in the discovery of cereblon-based protease-targeted chimeras with potential for therapeutic intervention.
Sign Up to like & getrecommendations! Published in 2022 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2022-0149
Abstract: Protease-targeted chimeras (PROTACs) have been employed as a novel therapeutic approach, utilizing the ubiquitin-proteasome system for targeted protein degradation. PROTACs are heterobifunctional molecules consisting of an E3 ligase ligand and a small-molecule inhibitor for recruiting… read more here.
Keywords: cereblon based; protease targeted; chemistry; protac molecules ... See more keywords