An Oral PROTAC Targeting HPK1 Degradation Potentiates Anti-Solid Tumor Immunity.
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DOI: 10.1002/adma.202411454
Abstract: Hematopoietic progenitor pinase1 (HPK1) knockout has been identified as an efficient route to enhance anti-tumor immune response. Here, this work develops an oral proteolysis targeting chimera (PROTAC) targeting HPK1 to efficiently and selectively degrade HPK1… read more here.
Keywords: protac; protac targeting; targeting hpk1; tumor ... See more keywords