Peptide-based PROTACs: Current Challenges and Future Perspectives.
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DOI: 10.2174/0929867330666230130121822
Abstract: Proteolysis-targeting chimeras (PROTACs) are an attractive means to target previously undruggable or drug-resistant mutant proteins. While small molecule-based PROTACs are stable and can cross cell membranes, there is limited availability of suitable small molecule warheads… read more here.
Keywords: peptide based; small molecule; protacs current; based protacs ... See more keywords