Designing HDAC-PROTACs: lessons learned so far.
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DOI: 10.4155/fmc-2021-0206
Abstract: Proteolysis-targeting chimeras (PROTACs) are a powerful tool to hijack the endogenous ubiquitin-proteasome system (UPS) and to degrade the intracellular proteins of therapeutic importance. Recently, two heterobifunctional degraders targeting hormone receptors headed into Phase II clinical… read more here.
Keywords: protacs lessons; learned far; designing hdac; lessons learned ... See more keywords