Deleterious variants in TAF7L cause human oligoasthenoteratozoospermia and its impairing histone to protamine exchange inducing reduced in vitro fertilization
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1099270
Abstract: Introduction Oligoasthenoteratozoospermia (OAT) is a major cause of infertility in males. Only a few pathogenic genes of OAT have been clearly identified till now. A large number of OAT-affected cases remain largely unknown. Methods Here,… read more here.
Keywords: protamine exchange; oligoasthenoteratozoospermia; fertilization; histone protamine ... See more keywords
The Art of Packaging the Sperm Genome: Molecular and Structural Basis of the Histone-To-Protamine Exchange
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.895502
Abstract: Male fertility throughout life hinges on the successful production of motile sperm, a developmental process that involves three coordinated transitions: mitosis, meiosis, and spermiogenesis. Germ cells undergo both mitosis and meiosis to generate haploid round… read more here.
Keywords: basis histone; exchange; protamine exchange; histone protamine ... See more keywords