Structural characterization of the linked NS2B‐NS3 protease of Zika virus
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12741
Abstract: The Zika virus (ZIKV) NS2B‐NS3 protease is an important drug target. The conventional flaviviral protease constructs used for structural studies contain the NS2B cofactor region linked to the NS3 protease domain via a glycine‐rich flexible… read more here.
Keywords: ns3 protease; protease; ns2b ns3; linker ... See more keywords
Nature Inspired Molecular Design: Stereoselective Synthesis of Bicyclic and Polycyclic Ethers for Potent HIV-1 Protease Inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "Asian journal of organic chemistry"
DOI: 10.1002/ajoc.201800255
Abstract: We have developed a conceptually new generation of non-peptidic HIV-1 protease inhibitors incorporating novel structural templates inspired by nature. This has resulted in protease inhibitors with exceptional potency and excellent pharmacological and drug-resistance profiles. The… read more here.
Keywords: polycyclic ethers; protease; chemistry; drug ... See more keywords
Thiazole‐based SARS‐CoV‐2 protease (COV Mpro) inhibitors: Design, synthesis, enzyme inhibition, and molecular modeling simulations
Sign Up to like & getrecommendations! Published in 2022 at "Archiv Der Pharmazie"
DOI: 10.1002/ardp.202200121
Abstract: As an attempt to contribute to the efforts of combating the pandemic virus severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) responsible for COVID‐19, new analogs of the repurposed drug nitazoxanide which showed promising inhibitory efficacy… read more here.
Keywords: inhibition; protease; molecular modeling; enzyme ... See more keywords
Identification and CRISPR/Cas9 Knockout of the Endogenous C1s Protease in CHO Cells Eliminates Aberrant Proteolysis of Recombinantly Expressed Proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.27016
Abstract: Proteolysis associated with recombinant protein expression in Chinese Hamster Ovary (CHO) cells has hindered the development of biologics including HIV vaccines. When expressed in CHO cells, the recombinant HIV envelope protein, gp120, undergoes proteolytic clipping… read more here.
Keywords: proteolysis; protease; cho cells; c1s protease ... See more keywords
Effects of lysosomal biotherapeutic recombinant protein expression on cell stress and protease and general host cell protein release in Chinese hamster ovary cells
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Progress"
DOI: 10.1002/btpr.2455
Abstract: Recombinant human Acid Alpha Glucosidase (GAA) is the therapeutic enzyme used for the treatment of Pompe disease, a rare genetic disorder characterized by GAA deficiency in the cell lysosomes (Raben et al., Curr Mol Med.… read more here.
Keywords: protein; protease; gaa; cell ... See more keywords
The Structure‐Function Relationship of Human Bleomycin Hydrolase: Mutation of a Cysteine Protease into a Serine Protease
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DOI: 10.1002/cbic.202200186
Abstract: Human bleomycin hydrolase (hBH) catalyzes deamidation of the anticancer drug bleomycins (BLM). This enzyme is involved in BLM detoxification and drug resistance. Herein, we report the putative BLM‐binding site and catalytic mechanism of hBH. The… read more here.
Keywords: protease; cysteine protease; serine protease; bleomycin hydrolase ... See more keywords
Design, Synthesis and X-ray Structural Studies of Potent HIV-1 Protease Inhibitors Containing C-4 Substituted Tricyclic Hexahydro-furofuran derivatives as P2 ligands.
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200058
Abstract: The design, synthesis, X-ray structural, and biological evaluation of a series of highly potent HIV-1 protease inhibitors are reported herein. These inhibitors incorporated novel cyclohexane-fused tricyclic bis -tetrahydrofuran as P2 ligands in combination with a… read more here.
Keywords: synthesis ray; protease; potent hiv; hiv protease ... See more keywords
Thymic stromal lymphopoietin is expressed in human corneal stromal cells and secreted upon protease‐activated receptor 1 activation
Sign Up to like & getrecommendations! Published in 2017 at "IUBMB Life"
DOI: 10.1002/iub.1644
Abstract: Thymic stromal lymphopoietin (TSLP) is an interleukin‐7 (IL‐7) like cytokine that triggers inflammatory responses through activating dendritic cell. It is demonstrated to be involved in a number of disorders, including cancer, gastrointestinal diseases, and autoimmune… read more here.
Keywords: corneal; protease; thymic stromal; stromal cells ... See more keywords
An in silico pharmacological approach toward the discovery of potent inhibitors to combat drug resistance HIV‐1 protease variants
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28181
Abstract: Protease inhibitors (PIs) are crucial drugs in highly active antiretroviral therapy for human immunodeficiency virus‐1 (HIV‐1) infections. However, resistance owing to mutations challenge the long‐term efficacy in the medication of HIV‐1‐infected individuals. Lopinavir (LPV) and… read more here.
Keywords: drug resistance; protease; hiv; resistance hiv ... See more keywords
Structure‐based pharmacophore modeling, virtual screening approaches to identifying the potent hepatitis C viral protease and polymerase novel inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30298
Abstract: Hepatitis C is an infectious disease that leads to acute and chronic liver illnesses. Currently, there are no effective vaccines against this deadly virus. Direct acting antiviral (DAA) drugs are given in the combination with… read more here.
Keywords: protease polymerase; polymerase; protease; virtual screening ... See more keywords
The effect of different protease inhibitors on stability of parathyroid hormone, insulin, and prolactin levels under different lag times and storage conditions until analysis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22144
Abstract: Proteolytic cleavage through proteases affects peptide hormone levels, which is of particular significance when the time interval between sampling and analysis is prolonged. We evaluated the stability of parathyroid hormone, insulin, and prolactin molecules (i)… read more here.
Keywords: hormone; protease; parathyroid hormone; insulin prolactin ... See more keywords