Inhibition of HIV-1 Protease by a Boronic Acid with High Oxidative Stability.
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DOI: 10.1021/acsmedchemlett.2c00464
Abstract: HIV-1 protease is an important target for pharmaceutical intervention in HIV infection. Extensive structure-based drug design led to darunavir becoming a key chemotherapeutic agent. We replaced the aniline group of darunavir with a benzoxaborolone to… read more here.
Keywords: hiv; hiv protease; inhibition hiv; darunavir ... See more keywords