Structure and mechanism of the γ-secretase intramembrane protease complex.
Sign Up to like & getrecommendations! Published in 2022 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2022.102373
Abstract: γ-Secretase is a membrane protein complex that proteolyzes within the transmembrane domain of >100 substrates, including those derived from the amyloid precursor protein and the Notch family of cell surface receptors. The nine-transmembrane presenilin is… read more here.
Keywords: structure mechanism; protease complex; structure; secretase ... See more keywords
YejM Modulates Activity of the YciM/FtsH Protease Complex To Prevent Lethal Accumulation of Lipopolysaccharide
Sign Up to like & getrecommendations! Published in 2020 at "mBio"
DOI: 10.1128/mbio.00598-20
Abstract: Gram-negative bacteria are encapsulated by an outer membrane (OM) that is impermeable to large and hydrophobic molecules. As such, these bacteria are intrinsically resistant to several clinically relevant antibiotics. To better understand how the OM… read more here.
Keywords: membrane; activity; protease complex; ycim ftsh ... See more keywords