Discovery, Synthesis, Pharmacological Profiling, and Biological Characterization of Brintonamides A-E, Novel Dual Protease and GPCR Modulators from a Marine Cyanobacterium.
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DOI: 10.1021/acs.jmedchem.8b00885
Abstract: Five novel modified linear peptides named brintonamides A-E (1-5) were discovered from a marine cyanobacterial sample collected from Brinton Channel, Florida Keys. The total synthesis of 1-5 in addition to two other structurally related analogues… read more here.
Keywords: protease; discovery synthesis; protease gpcr; cancer ... See more keywords