Inactivation of the serine protease HTRA1 inhibits tumor growth by deregulating angiogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0258-4
Abstract: The serine protease HTRA1 is involved in several vascular diseases and its expression is often deregulated in cancer. We aimed at identifying how HTRA1 in the vasculature affects tumor growth. Here we report that silencing… read more here.
Keywords: angiogenesis; htra1; serine protease; protease htra1 ... See more keywords
Inhibition of the serine protease HtrA1 by SerpinE2 suggests an extracellular proteolytic pathway in the control of neural crest migration
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DOI: 10.1101/2023.09.05.556243
Abstract: We previously showed that SerpinE2 and the serine protease HtrA1 modulate fibroblast growth factor (FGF) signaling in germ layer specification and head-to-tail development of Xenopus embryos. Here we present an extracellular proteolytic mechanism involving this… read more here.
Keywords: migration; serine protease; htra1; protease htra1 ... See more keywords
Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy.
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DOI: 10.1681/asn.2020101395
Abstract: BACKGROUND Identification of target antigens PLA2R, THSD7A, NELL1, or Semaphorin-3B can explain the majority of cases of primary membranous nephropathy (MN). However, target antigens remain unidentified in 15%-20% of patients. METHODS A multipronged approach, using… read more here.
Keywords: serine protease; target; htra1; protease htra1 ... See more keywords