Thermodynamic characterization of a macrocyclic Zika virus NS2B/NS3 protease inhibitor and its acyclic analogs
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200518
Abstract: Cyclization of small molecules is a widely applied strategy in drug design for ligand optimization to improve affinity, as it eliminates the putative need for structural preorganization of the ligand before binding, or to improve… read more here.
Keywords: virus ns2b; macrocyclic zika; zika virus; protease inhibitor ... See more keywords
Up‐regulation of secretory leukocyte protease inhibitor in human samples might have a potential role of predicting prostate cancer recurrence and progression after surgery and hormonal therapy
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5134
Abstract: Using new castration‐resistant prostate cancer (CRPC) cell lines developed from LNCaP cells as a model for CRPC, we searched for novel biomarkers by analyzing the proteins secreted in culture supernatants. The results showed that the… read more here.
Keywords: prostate cancer; progression; leukocyte protease; protease inhibitor ... See more keywords
Safety, Tolerability, and Pharmacokinetics of Intravenous Doses of PF‐07304814, a Phosphate Prodrug Protease Inhibitor for the Treatment of SARS‐CoV‐2, in Healthy Adult Participants
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1174
Abstract: Studies on targeted antivirals for treatment of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the cause of the ongoing pandemic, are limited. PF‐07304814 (lufotrelvir) is the phosphate prodrug of PF‐00835231, a protease inhibitor targeting the… read more here.
Keywords: safety; protease inhibitor; treatment; phosphate prodrug ... See more keywords
Potato protease inhibitor II prevents obesity by inducing browning of white adipose tissue in mice via β3 adrenergic receptor signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7451
Abstract: There are currently few effective and safe pharmacologic means for inducing beige adipogenesis in humans. This study highlights the role of potato protease inhibitor II (PPI II) in regulating the browning of adipose tissue. The… read more here.
Keywords: protease inhibitor; potato protease; adipose tissue; white adipose ... See more keywords
Isolation, purification and characterization of a pH tolerant and temperature stable proteinaceous protease inhibitor from marine Pseudomonas mendocina
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Letters"
DOI: 10.1007/s10529-017-2424-0
Abstract: ObjectivesAn extracellular protease inhibitor (BTPI-301) of trypsin was purified and characterized from an isolate of Pseudomonas mendocina.ResultsBTPI-301was purified to homogeneity by (NH4)2SO4, precipitation, DEAE Sepharose and CNBr-activated Sepharose chromatography. Homogeneity was proved by native PAGE… read more here.
Keywords: protease inhibitor; btpi 301; inhibitor; trypsin ... See more keywords
Purification and characterization of a new protease inhibitor from Spatholobus parviflorus seeds which inhibits the larval gut proteases of Spodoptera mauritia (Boisduval) (Lepidoptera: Noctuidae)
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Plant Biochemistry and Biotechnology"
DOI: 10.1007/s13562-021-00685-x
Abstract: Plant protease inhibitors are defense molecules against pests, predators and pathogens. We purified and characterized a new 14 kDa protease inhibitor from the seeds of Spatholobus parviflorus by ammonium sulfate precipitation, ion exchanges chromatography, trypsin-affinity chromatography… read more here.
Keywords: spatholobus parviflorus; protease inhibitor; protease; larval gut ... See more keywords
Do protease inhibitor‐containing combination antiretroviral therapy regimens increase risk of spontaneous preterm birth in pregnant HIV‐Positive women?: 7
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Obstetrics and Gynecology"
DOI: 10.1016/j.ajog.2017.08.087
Abstract: administration with a meal or soft foods, and the impact of high doses of secnidazole on cardiac safety. SYM-1219 was administered in either applesauce, yogurt, or pudding, followed by 240 mL of water. Serial blood… read more here.
Keywords: protease inhibitor; sym 1219; metabolism; sym ... See more keywords
Inhibition of gut proteases and development of dengue vector, Aedes aegypti by Allium sativum protease inhibitor
Sign Up to like & getrecommendations! Published in 2018 at "Acta Ecologica Sinica"
DOI: 10.1016/j.chnaes.2018.01.002
Abstract: Abstract The paper describes the bio efficacy of a protease inhibitor; isolated from Allium sativum ‘garlic’ (ASPI); against Aedes aegypti mosquito, a well-known transmitter of dengue and Chikungunya. The purification of protease inhibitor from Allium… read more here.
Keywords: protease inhibitor; aedes aegypti; inhibitor; protease ... See more keywords
Protease inhibitor-based direct-acting antivirals are associated with increased risk of aminotransferase elevations but not hepatic dysfunction or decompensation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2021.07.021
Abstract: BACKGROUND & AIMS Cases of acute liver injury (ALI) have been reported among chronic hepatitis C virus-infected initiators of protease inhibitor (PI)-based direct-acting antiviral (DAA) regimens, predominately with decompensated cirrhosis in whom these therapies are… read more here.
Keywords: protease inhibitor; risk; inhibitor based; dysfunction ... See more keywords
α-Lipoic acid blocks the GMCSF induced protease/protease inhibitor spectrum associated with fetal membrane weakening in-vitro.
Sign Up to like & getrecommendations! Published in 2020 at "Placenta"
DOI: 10.1016/j.placenta.2020.06.021
Abstract: INTRODUCTION We use an in-vitro human fetal membrane (FM) explant-based model to study inflammation-induced FM weakening, a prerequisite for PPROM. In this system, GMCSF is a critical intermediate, both necessary and sufficient for TNFα and… read more here.
Keywords: protease inhibitor; gmcsf induced; protease; induced weakening ... See more keywords
Simultaneous Delivery of Doxorubicin and Protease Inhibitor Derivative to Solid Tumors via Star-Shaped Polymer Nanomedicines Overcomes P-gp- and STAT3-Mediated Chemoresistance.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00256
Abstract: The derivative of protease inhibitor ritonavir (5-methyl-4-oxohexanoic acid ritonavir ester; RD) was recently recognized as a potent P-gp inhibitor and cancerostatic drug inhibiting the proteasome and STAT3 signaling. Therefore, we designed high-molecular-weight HPMA copolymer conjugates… read more here.
Keywords: star; dox; star dox; simultaneous delivery ... See more keywords