Protease nexin-1 protects against Alzheimer’s disease by regulating the sonic hedgehog signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Neuroscience"
DOI: 10.1080/00207454.2020.1773821
Abstract: Abstract Objective To explore the role of protease nexin-1 (PN-1) in Alzheimer’s disease (AD) via the sonic hedgehog (SHH) pathway. Methods PN-1 lentiviral activation particles were injected into APP/PS1 transgenic AD and wild-type (WT) mice;… read more here.
Keywords: alzheimer disease; ht22 cells; protease nexin; shh pathway ... See more keywords
Fusion to Human Serum Albumin Extends the Circulatory Half-Life and Duration of Antithrombotic Action of the Kunitz Protease Inhibitor Domain of Protease Nexin 2
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000487168
Abstract: Background/Aims: The Kunitz Protease Inhibitor (KPI) domain of protease nexin 2 (PN2) potently inhibits coagulation factor XIa. Recombinant KPI has been shown to inhibit thrombosis in mouse models, but its clearance from the murine circulation… read more here.
Keywords: protease inhibitor; protease; domain protease; protease nexin ... See more keywords
Protease Nexin-1 in the Cardiovascular System: Wherefore Art Thou?
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.652852
Abstract: The balance between proteases and protease inhibitors plays a critical role in tissue remodeling during cardiovascular diseases. Different serine protease inhibitors termed serpins, which are expressed in the cardiovascular system, can exert a fine-tuned regulation… read more here.
Keywords: protease nexin; cardiovascular system; protease; protease activities ... See more keywords