Structure‐based pharmacophore modeling, virtual screening approaches to identifying the potent hepatitis C viral protease and polymerase novel inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30298
Abstract: Hepatitis C is an infectious disease that leads to acute and chronic liver illnesses. Currently, there are no effective vaccines against this deadly virus. Direct acting antiviral (DAA) drugs are given in the combination with… read more here.
Keywords: protease polymerase; polymerase; protease; virtual screening ... See more keywords
Host cell p53 associates with the feline calicivirus major viral capsid protein VP1, the protease-polymerase NS6/7, and the double-stranded RNA playing a role in virus replication
Sign Up to like & getrecommendations! Published in 2020 at "Virology"
DOI: 10.1016/j.virol.2020.08.008
Abstract: p53 is implicated in several cellular pathways such as induction of cell-cycle arrest, differentiation, senescence, and apoptosis. p53 is activated by a broad range of stress signals, including viral infections. While some viruses activate p53,… read more here.
Keywords: p53 associates; protease polymerase; vp1 protease; polymerase ns6 ... See more keywords