The Structure‐Function Relationship of Human Bleomycin Hydrolase: Mutation of a Cysteine Protease into a Serine Protease
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DOI: 10.1002/cbic.202200186
Abstract: Human bleomycin hydrolase (hBH) catalyzes deamidation of the anticancer drug bleomycins (BLM). This enzyme is involved in BLM detoxification and drug resistance. Herein, we report the putative BLM‐binding site and catalytic mechanism of hBH. The… read more here.
Keywords: protease; cysteine protease; serine protease; bleomycin hydrolase ... See more keywords
Unravelling high-affinity binding compounds towards transmembrane protease serine 2 enzyme in treating SARS-CoV-2 infection using molecular modelling and docking studies
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DOI: 10.1016/j.ejphar.2020.173688
Abstract: The coronavirus disease-19 (COVID-19) outbreak that is caused by a highly contagious severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a zoonotic pandemic, with approximately 24.5 million positive cases and 8.3 lakhs deaths globally. The… read more here.
Keywords: protease serine; transmembrane protease; high affinity; docking studies ... See more keywords
Upregulation of the transmembrane protease serine 3 mRNA level in radioresistant colorectal cancer tissues.
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DOI: 10.2217/bmm-2021-0649
Abstract: Aim: To investigate the clinical role of transmembrane protease serine 3 (TMPRSS3) in radioresistance and prognosis of colorectal cancer (CRC). Methods: Standardized mean difference (SMD) and summary area under the curve (AUC) of TMPRSS3 were… read more here.
Keywords: crc; tmprss3; transmembrane protease; colorectal cancer ... See more keywords