Ubiquitin-Specific Protease 7 (USP7) as a Promising Therapeutic Target for Drug Discovery: From Mechanisms to Therapies.
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DOI: 10.1021/acs.jmedchem.5c00102
Abstract: Protein ubiquitination is a reversible post-translational modification regulated by ubiquitin-conjugating and deubiquitinating enzymes (DUBs). Ubiquitin-specific protease 7 (USP7), a well-characterized DUB, plays multifaceted roles in various cellular processes, making it a promising therapeutic target. The… read more here.
Keywords: protease usp7; drug discovery; ubiquitin specific; therapeutic target ... See more keywords
Targeting Ubiquitin-Specific Protease 7 (USP7): A Pharmacophore-Guided Drug Repurposing and Physics-Based Molecular Simulation Study
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DOI: 10.1021/acsomega.5c03150
Abstract: Ubiquitin-Specific Protease 7 (USP7) has emerged as a critical therapeutic target in cancer due to its regulatory roles of tumor suppressors, oncoproteins, and epigenetic modifiers. In this study, we present a comprehensive drug repurposing strategy… read more here.
Keywords: drug repurposing; protease usp7; physics; ubiquitin specific ... See more keywords
A patent review of ubiquitin-specific protease 7 (USP7) inhibitors (2014-present)
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DOI: 10.1080/13543776.2022.2058873
Abstract: ABSTRACT Introduction Ubiquitin-specific protease 7 (USP7) plays a critical role in multiple signaling pathways, and many recent studies have proved its association with many diseases. The USP7-murine double minute 2-p53 pathway and the relationship between… read more here.
Keywords: specific protease; ubiquitin specific; protease usp7; usp7 inhibitors ... See more keywords