Mapping prohormone processing by proteases in human enteroendocrine cells using genetically engineered organoid models
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2212057119
Abstract: Significance Enteroendocrine cells control key physiological processes such as appetite and insulin secretion through the secretion of neurotransmitters and peptide hormones. The bioactive peptides are subject to complex proteolytic processing essential for their activation or… read more here.
Keywords: enteroendocrine cells; processing; proteases human; mapping prohormone ... See more keywords
Quantifying the Effects of Different Neutral Proteases on Human Islet Integrity
Sign Up to like & getrecommendations! Published in 2017 at "Cell Transplantation"
DOI: 10.1177/0963689717727544
Abstract: Efficient islet release from the pancreas requires the combination of collagenase, neutral protease (cNP), or thermolysin (TL). Recently, it has been shown that clostripain (CP) may also contribute to efficient islet release from the human… read more here.
Keywords: cnp; islet; islet integrity; proteases human ... See more keywords