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   Articles with "proteasome" as a keyword



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Structure‐Based Design of Fluorogenic Substrates Selective for Human Proteasome Subunits

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recommendations! Published in 2020 at "Chembiochem"

DOI: 10.1002/cbic.202000375

Abstract: Proteasomes are established therapeutic targets for hematological cancers and promising targets for autoimmune diseases. In the past, we have designed and synthesized mechanism‐based proteasome inhibitors that are selective for the individual catalytic activities of human… read more here.

Keywords: design fluorogenic; proteasome; structure based; based design ... See more keywords

Unveiling the Potential of a New β‐Cyclodextrin‐Suxibuzone Conjugate in Proteasome Regulation

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recommendations! Published in 2025 at "Chemmedchem"

DOI: 10.1002/cmdc.202500401

Abstract: The proteasome is a central component of the cellular machinery responsible for degrading misfolded or damaged proteins, thereby maintaining protein homeostasis. Dysregulation of proteasome activity has been implicated in various diseases, including neurodegenerative disorders and… read more here.

Keywords: proteasome; suxibuzone; new cyclodextrin; conjugate ... See more keywords

Stress-Induced Reorganization of Proteasomes Through Diffusion and Cytoskeleton-Dependent Mechanisms.

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recommendations! Published in 2025 at "Small"

DOI: 10.1002/smll.202506260

Abstract: Abstract Proteasomes are abundant molecular machines distributed throughout the eukaryotic cell to facilitate protein degradation. How their dynamic localization adapts to proteostasis requirements remains an area of active study. Recent studies from the authors show… read more here.

Keywords: cytoskeleton dependent; stress; reorganization; proteasome ... See more keywords

PCPS: A Web Server to Predict Proteasomal Cleavage Sites.

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recommendations! Published in 2020 at "Methods in molecular biology"

DOI: 10.1007/978-1-0716-0389-5_23

Abstract: The proteasome complex is mainly responsible for proteolytic degradation of cytosolic proteins, generating the C-terminus of MHC I-restricted peptide ligands and CD8 T cell epitopes. Therefore, prediction of proteasomal cleavage sites is relevant for anticipating… read more here.

Keywords: proteasomal cleavage; cleavage; proteasome; pcps web ... See more keywords

Bassoon inhibits proteasome activity via interaction with PSMB4

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recommendations! Published in 2020 at "Cellular and Molecular Life Sciences"

DOI: 10.1007/s00018-020-03590-z

Abstract: Abstract Proteasomes are protein complexes that mediate controlled degradation of damaged or unneeded cellular proteins. In neurons, proteasome regulates synaptic function and its dysfunction has been linked to neurodegeneration and neuronal cell death. However, endogenous… read more here.

Keywords: protein; proteasome; psmb4; activity ... See more keywords

Putting it all together: intrinsic and extrinsic mechanisms governing proteasome biogenesis

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recommendations! Published in 2017 at "Frontiers in Biology"

DOI: 10.1007/s11515-017-1439-1

Abstract: BackgroundThe 26S proteasome is at the heart of the ubiquitin-proteasome system, which is the key cellular pathway for the regulated degradation of proteins and enforcement of protein quality control. The 26S proteasome is an unusually… read more here.

Keywords: putting together; proteasome biogenesis; proteasome; proteasome assembly ... See more keywords

NMR 1H, 13C, 15N backbone and side chain resonance assignment of the N-terminal domain of yeast proteasome lid subunit Rpn5

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recommendations! Published in 2019 at "Biomolecular NMR Assignments"

DOI: 10.1007/s12104-018-9840-5

Abstract: The 26S proteasome is responsible for the selective, ATP-dependent degradation of polyubiquitinated proteins in eukaryotic cells. It consists of a 20S barrel-shaped core particle capped by two 19S regulatory particle at both ends. The Rpn5… read more here.

Keywords: terminal domain; 13c 15n; proteasome; subunit ... See more keywords

Dynamic changes of proteasome and protective effect of bortezomib, a proteasome inhibitor, in mice with acute pancreatitis.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.09.066

Abstract: The proteasome is involved in the activation of NF-κB and can regulate the progression of inflammatory diseases. However, the role of proteasome in acute pancreatitis (AP) has not been demonstrated. In this study, we first… read more here.

Keywords: acute pancreatitis; proteasome; inhibitor; mice ... See more keywords

Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug.

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recommendations! Published in 2019 at "Biochimie"

DOI: 10.1016/j.biochi.2019.03.015

Abstract: Auranofin is a gold (I)-containing compound used for the treatment of rheumatic arthritis. Auranofin has anticancer activity in animal models and is approved for clinical trials for lung and ovarian carcinomas. Both the cytosolic and… read more here.

Keywords: thioredoxin reductase; inhibitor; proteasome; activity ... See more keywords

Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles.

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recommendations! Published in 2019 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2018.12.064

Abstract: The potential of specific proteasome inhibitors to act as anti-cancer agents has attracted intensive investigations. The proteasome can be covalently inhibited by epoxyketone derivatives via a two-step reaction. Several computational approaches have been developed to… read more here.

Keywords: docking modelling; proteasome inhibitors; proteasome; covalent docking ... See more keywords

Biological consequences of structural and functional proteasome diversity

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recommendations! Published in 2018 at "Heliyon"

DOI: 10.1016/j.heliyon.2018.e00894

Abstract: Cell homeostasis and regulation of metabolic pathways are ensured by synthesis, proper folding and efficient degradation of a vast amount of proteins. Ubiquitin-proteasome system (UPS) degrades most intracellular proteins and thus, participates in regulation of… read more here.

Keywords: consequences structural; proteasome; proteasome diversity; structural functional ... See more keywords