Design, Synthesis, and Biological Evaluation of Potent 20S Proteasome Activators for the Potential Treatment of α-Synucleinopathies.
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DOI: 10.1021/acs.jmedchem.1c02158
Abstract: While neurodegenerative diseases affect millions of patients worldwide, there are insufficient available therapeutics to halt or slow down the progression of these diseases. A key pathological feature of several neurodegenerative diseases is the oligomerization and… read more here.
Keywords: 20s proteasome; design synthesis; synthesis biological; biological evaluation ... See more keywords