SolidâPhase Synthesis and Application of a Clickable Version of Epoxomicin for Proteasome Activity Analysis
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202100710
Abstract: Degradation of proteins by the proteasome is an essential cellular process and one that many wish to study in a variety of disease types. There are commercially available probes that can monitor proteasome activity in… read more here.
Keywords: proteasome activity; activity; application clickable; synthesis application ... See more keywords
Effect of Sperm 26S Proteasome on Embryo Formation and Development in In Vitro Fertilization
Sign Up to like & getrecommendations! Published in 2022 at "Reproductive Sciences"
DOI: 10.1007/s43032-022-00916-z
Abstract: The aim of this study was to evaluate the effects of sperm proteasome activity on fertilization outcome and embryo development after IVF. Following density gradient centrifugation for IVF purpose, the spermatozoa of 84 infertile patients… read more here.
Keywords: 26s proteasome; development; fertilization; proteasome activity ... See more keywords
CRL4DCAF2 is required for mature T-cell expansion via Aurora B-regulated proteasome activity.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2018.08.006
Abstract: The proliferation of T cells in peripheral lymphoid tissues requires T cell receptor (TCR)-mediated cell cycle entry. However, the underlying mechanism regulating cell cycle progression in mature T cells is incompletely understood. Here, we have… read more here.
Keywords: mature; cell expansion; crl4dcaf2; proteasome activity ... See more keywords
Proteasome activity regulated by charged gold nanoclusters: Implications for neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2020 at "Nano Today"
DOI: 10.1016/j.nantod.2020.100933
Abstract: Abstract The 20S proteasome, the catalytic core particle of 26S proteasome, degrades a wide range of intracellular proteins, which is essential for many cellular processes. Herein, we have found that the 20S proteasome activity is… read more here.
Keywords: 20s proteasome; gold nanoclusters; proteasome activity; neurodegenerative diseases ... See more keywords
Fluorescent Probes with Unnatural Amino Acids to Monitor Proteasome Activity in Real-Time.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical biology"
DOI: 10.1021/acschembio.0c00634
Abstract: The proteasome is an essential protein complex that, when dysregulated, can result in various diseases in eukaryotic cells. As such, understanding the enzymatic activity of the proteasome and what can alter it is crucial to… read more here.
Keywords: amino acids; proteasome activity; unnatural amino; activity ... See more keywords
Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00489
Abstract: The 20S proteasome is the main protease for the degradation of oxidatively damaged and intrinsically disordered proteins. When accumulation of disordered or oxidatively damaged proteins exceeds proper clearance in neurons, imbalanced pathway signaling or aggregation… read more here.
Keywords: small molecule; proteasome activity; 20s proteasome; disordered proteins ... See more keywords
Carfilzomib-induced endothelial dysfunction, recovery of proteasome activity, and prediction of cardiovascular complications: a prospective study
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia"
DOI: 10.1038/s41375-021-01141-4
Abstract: Carfilzomib (CFZ) improves survival in relapsed/refractory multiple myeloma but is associated with cardiovascular adverse events (CVAEs). We prospectively investigated the effect of CFZ on endothelial function and associations with CVAEs. Forty-eight patients treated with Kd… read more here.
Keywords: cfz; recovery; fmd; proteasome activity ... See more keywords
Proteasome activity modulates amyloid toxicity.
Sign Up to like & getrecommendations! Published in 2022 at "FEMS yeast research"
DOI: 10.1093/femsyr/foac004
Abstract: Alzheimer's Disease (AD) is responsible for 60-80% of identified cases of dementia. While the generation and accumulation of amyloid precursor protein (APP) fragments is accepted as a key step in AD pathogenesis, the precise role… read more here.
Keywords: modulates amyloid; proteasome; activity modulates; activity ... See more keywords
PDE5A Suppresses Proteasome Activity Leading to Insulin Resistance in C2C12 Myotubes
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Endocrinology"
DOI: 10.1155/2019/3054820
Abstract: Objective The involvement of phosphodiesterase type 5 (PDE5) in the development of insulin resistance has been reported recently. However, the underlying molecular mechanism remains unclear. The present study aims at investigating the potential impacts of… read more here.
Keywords: insulin; overexpression; proteasome activity; insulin resistance ... See more keywords
A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress
Sign Up to like & getrecommendations! Published in 2017 at "BMC Cancer"
DOI: 10.1186/s12885-017-3530-z
Abstract: BackgroundMantle cell lymphoma (MCL) is a B-cell hemopathy characterized by the t(11;14) translocation and the aberrant overexpression of cyclin D1. This results in an unrestrained cell proliferation. Other genetic alterations are common in MCL cells… read more here.
Keywords: genotoxic stress; cell lines; 26s proteasome; resistance ... See more keywords
Lewis y antigen promotes p27 degradation by regulating ubiquitin-proteasome activity
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.22617
Abstract: As a tumor-associated carbohydrate antigen, elevated expression of Lewis y promotes the malignant behaviors of tumor cells. Although our preliminary study showed that the increased expression of Lewis y antigen decreased the expression of cell… read more here.
Keywords: degradation; antigen; proteasome activity; lewis antigen ... See more keywords