Putting it all together: intrinsic and extrinsic mechanisms governing proteasome biogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Biology"
DOI: 10.1007/s11515-017-1439-1
Abstract: BackgroundThe 26S proteasome is at the heart of the ubiquitin-proteasome system, which is the key cellular pathway for the regulated degradation of proteins and enforcement of protein quality control. The 26S proteasome is an unusually… read more here.
Keywords: putting together; proteasome biogenesis; proteasome; proteasome assembly ... See more keywords
Regulation of proteasome assembly and activity in health and disease
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/s41580-018-0040-z
Abstract: The proteasome degrades most cellular proteins in a controlled and tightly regulated manner and thereby controls many processes, including cell cycle, transcription, signalling, trafficking and protein quality control. Proteasomal degradation is vital in all cells… read more here.
Keywords: degradation; proteasome; proteasome assembly; physiology ... See more keywords
Phosphatase UBLCP1 controls proteasome assembly
Sign Up to like & getrecommendations! Published in 2017 at "Open Biology"
DOI: 10.1098/rsob.170042
Abstract: Ubiquitin-like domain-containing C-terminal domain phosphatase 1 (UBLCP1), an FCP/SCP phosphatase family member, was identified as the first proteasome phosphatase. UBLCP1 binds to proteasome subunit Rpn1 and dephosphorylates the proteasome in vitro. However, it is still… read more here.
Keywords: phosphatase; phosphatase ublcp1; proteasome assembly; ublcp1 controls ... See more keywords
Structural Analysis of Mycobacterium tuberculosis Homologues of the Eukaryotic Proteasome Assembly Chaperone 2 (PAC2)
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bacteriology"
DOI: 10.1128/jb.00846-16
Abstract: ABSTRACT A previous bioinformatics analysis identified the Mycobacterium tuberculosis proteins Rv2125 and Rv2714 as orthologs of the eukaryotic proteasome assembly chaperone 2 (PAC2). We set out to investigate whether Rv2125 or Rv2714 can function in… read more here.
Keywords: proteasome assembly; analysis; tuberculosis; rv2125 rv2714 ... See more keywords
Prognostic and Immune Infiltration Value of Proteasome Assembly Chaperone (PSMG) Family Genes in Lung Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Medical Sciences"
DOI: 10.7150/ijms.78590
Abstract: The complexity of lung adenocarcinoma (LUAD) including many interacting biological processes makes it difficult to find therapeutic biomarkers for treatment. Previous studies demonstrated that PSMG (proteasome assembly chaperone) family members regulate the degradation of abnormal… read more here.
Keywords: family; lung adenocarcinoma; psmg family; family genes ... See more keywords