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Proteasome associated function of UCH37 is evolutionarily conserved in Plasmodium parasites

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0 Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-80433-y

Abstract: Ubiquitin C-terminal hydrolase 37 (UCH37 also known as UCHL5) is a conserved deubiquitinating enzyme (DUB) with dual roles in proteasomal degradation and chromatin remodeling in humans. Its Plasmodium falciparum ortholog, PfUCH37, is unusual in that… read more here.

Keywords: associated function; conserved plasmodium; proteasome associated; function uch37 ... See more keywords

Proteasome-associated HECT-type ubiquitin ligase activity is required for plant immunity

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0 Published in 2018 at "PLoS Pathogens"

DOI: 10.1371/journal.ppat.1007447

Abstract: Regulated degradation of proteins by the 26S proteasome plays important roles in maintenance and signalling in eukaryotic cells. Proteins are marked for degradation by the action of E3 ligases that site-specifically modify their substrates by… read more here.

Keywords: proteasome associated; immunity; proteasome; ubiquitin ligase ... See more keywords

Small-Molecule Inhibitors Targeting Proteasome-Associated Deubiquitinases

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0 Published in 2021 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms22126213

Abstract: The 26S proteasome is the principal protease for regulated intracellular proteolysis. This multi-subunit complex is also pivotal for clearance of harmful proteins that are produced throughout the lifetime of eukaryotes. Recent structural and kinetic studies… read more here.

Keywords: proteasome associated; proteasome; small molecule; targeting proteasome ... See more keywords