Proteomic Signature of Neuroblastoma Cells UKF-NB-4 Reveals Key Role of Lysosomal Sequestration and the Proteasome Complex in Acquiring Chemoresistance to Cisplatin.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.8b00867
Abstract: Cisplatin (CDDP) is a widely used agent in the treatment of neuroblastoma. Unfortunately, the development of acquired chemoresistance limits its clinical use. To gain a detailed understanding of the mechanisms underlying the development of such… read more here.
Keywords: proteasome complex; chemoresistance; cisplatin; neuroblastoma ... See more keywords
Deregulation of the 19S proteasome complex increases yeast resistance to 4‐NQO and oxidative stress via upregulation of Rpn4‐ and proteasome‐dependent stress responsive genes
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DOI: 10.1093/femsyr/foz002
Abstract: Abstract The 26S proteasome participates in cell stress responses via its ability to degrade regulatory and damaged proteins. In yeast, mutations in the subunits of the 19S proteasome regulatory subcomplex cause hyper‐resistance to 4‐nitroquinoline‐1‐oxide (4‐NQO),… read more here.
Keywords: 19s proteasome; proteasome complex; resistance nqo; stress ... See more keywords