Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion
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DOI: 10.1016/j.isci.2019.01.018
Abstract: Summary We identified ∼30-mer amyloid-β protein (Aβ) assemblies, termed amylospheroids, from brains of patients with Alzheimer disease (AD) as toxic entities responsible for neurodegeneration and showed that Na+,K+-ATPase α3 (NAKα3) is the sole target of… read more here.
Keywords: excitatory neurons; proteasome inhibition; assemblies accumulate; accumulate excitatory ... See more keywords
Longitudinal monoaminergic PET imaging of chronic proteasome inhibition in minipigs
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DOI: 10.1038/s41598-018-34084-5
Abstract: Impairment of the ubiquitin proteasome system has been implicated in Parkinson’s disease. We used positron emission tomography to investigate longitudinal effects of chronic intracerebroventricular exposure to the proteasome inhibitor lactacystin on monoaminergic projections and neuroinflammation.… read more here.
Keywords: proteasome inhibition; pet imaging; longitudinal monoaminergic; chronic proteasome ... See more keywords
Inhibition of calpain-1 stabilizes TCF11/Nrf1 but does not affect its activation in response to proteasome inhibition
Sign Up to like & getrecommendations! Published in 2018 at "Bioscience Reports"
DOI: 10.1042/bsr20180393
Abstract: Protein degradation is essential to compensate for the damaging effects of proteotoxic stress. To ensure protein and redox homeostasis in response to proteasome inhibition, the cleavage and nuclear translocation of the endoplasmic reticulum (ER)-bound transcription… read more here.
Keywords: proteasome inhibition; tcf11 nrf1; calpain; activation ... See more keywords
Missense UROS mutations causing congenital erythropoietic porphyria reduce UROS homeostasis that can be rescued by proteasome inhibition
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DOI: 10.1093/hmg/ddx067
Abstract: Congenital erythropoietic porphyria (CEP) is an inborn error of heme biosynthesis characterized by uroporphyrinogen III synthase (UROS) deficiency resulting in deleterious porphyrin accumulation in blood cells responsible for hemolytic anemia and cutaneous photosensitivity. We analyzed… read more here.
Keywords: protein; homeostasis; proteasome inhibition; erythropoietic porphyria ... See more keywords
Abstract A28: Targeting the epigenetic state regulating cancer cell vulnerability to proteasome inhibition
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.pmccavuln16-a28
Abstract: The proteasome is a central regulator of protein homeostasis in all eukaryotes. Targeted pharmaceutical inhibition of the proteasome complex has been implemented as a successful therapeutic strategy to treat several cancers including multiple myeloma. Unfortunately,… read more here.
Keywords: state; proteasome inhibition; cancer cell; cancer ... See more keywords
Bortezomib Inhibits Lung Fibrosis and Fibroblast Activation Without Proteasome Inhibition.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2021-0112oc
Abstract: The FDA-approved proteasomal inhibitor bortezomib (BTZ) has attracted interest for its potential anti-fibrotic actions. However, neither its in vivo efficacy in lung fibrosis nor its dependence on proteasome inhibition has been conclusively defined. In this… read more here.
Keywords: proteasome inhibition; fibroblast activation; btz; fibrosis ... See more keywords
Increased Physiological GDNF Levels Have No Effect on Dopamine Neuron Protection and Restoration in a Proteasome Inhibition Mouse Model of Parkinson’s Disease
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DOI: 10.1523/eneuro.0097-22.2023
Abstract: Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disease that comprises a range of motor and nonmotor symptoms. Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of dopamine neurons in vitro and in vivo,… read more here.
Keywords: parkinson disease; proteasome inhibition; model; gdnf ... See more keywords
Proteasome Inhibition Is an Effective Treatment Strategy for Microsporidia Infection in Honey Bees
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DOI: 10.3390/biom11111600
Abstract: The microsporidia Nosema ceranae is an obligate intracellular parasite that causes honey bee mortality and contributes to colony collapse. Fumagillin is presently the only pharmacological control for N. ceranae infections in honey bees. Resistance is… read more here.
Keywords: proteasome inhibition; honey; treatment strategy; microsporidia infection ... See more keywords
Transcriptional factor Nrf2 is essential for aggresome formation during proteasome inhibition
Sign Up to like & getrecommendations! Published in 2019 at "Biomedical Reports"
DOI: 10.3892/br.2019.1247
Abstract: Aggrephagy, the aggresome-related protein degradation system, represents a protective cellular response to shuttle misfolded proteins into the microtubule-organizing center for degradation through the autophagic pathway during stress conditions, including heat shock, oxidative stress and proteasome… read more here.
Keywords: factor nrf2; formation; proteasome inhibition; aggresome formation ... See more keywords