Inhibition of proteasome, but not lysosome, upregulates organic anion transporter 3 in vitro and in vivo.
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DOI: 10.2139/ssrn.4252414
Abstract: Organic anion transporter 3 (OAT3), an indispensable basolateral membrane transporter predominantly distributed in the kidney proximal tubules, mediated the systemic clearance of substrates including clinical drugs, nutrients, endogenous and exogenous metabolites, toxins, and critically sustains… read more here.
Keywords: vitro vivo; inhibition; proteasome lysosome; transporter ... See more keywords