Proteasome-mediated protein degradation is enhanced by fusion ubiquitin with unstructured degron.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.088
Abstract: Methods to induce proteasomal degradation of unwanted proteins are valuable in biomedical studies and thus receive increasing attention. For efficient degradation, the proteasome requires both a ubiquitin tag, which delivers substrates to the proteasome, and… read more here.
Keywords: degradation; proteasome mediated; degron; ubiquitin ... See more keywords
Global views of proteasome-mediated degradation by mass spectrometry.
Sign Up to like & getrecommendations! Published in 2019 at "Expert review of proteomics"
DOI: 10.1080/14789450.2019.1645601
Abstract: Introduction: Degradation of proteins by cellular proteasomes is critical for the fidelity of protein homeostasis and proper cell function. Indeed, perturbations in proteasome function, as well as the degradation of specific substrates, are associated with… read more here.
Keywords: global views; degradation; mass spectrometry; proteasome mediated ... See more keywords