Targeting Protein-Protein Interactions in the Ubiquitin-Proteasome Pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in protein chemistry and structural biology"
DOI: 10.1016/bs.apcsb.2017.09.001
Abstract: The ubiquitin-proteasome pathway (UPP) is a major venue for controlled intracellular protein degradation in Eukaryota. The machinery of several hundred proteins is involved in recognizing, tagging, transporting, and cleaving proteins, all in a highly regulated… read more here.
Keywords: protein; protein interactions; proteasome pathway; protein protein ... See more keywords
Drosophila Argonaute2 turnover is regulated by the ubiquitin proteasome pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.039
Abstract: Argonaute (AGO) proteins play a central role in the RNA interference (RNAi) pathway, which is a cytoplasmic mechanism important for post-transcriptional regulation of gene expression. In Drosophila, AGO2 also functions in the nucleus to regulate… read more here.
Keywords: ago2 protein; proteasome pathway; turnover; drosophila argonaute2 ... See more keywords
SUMOylation of MCL1 protein enhances its stability by regulating the ubiquitin-proteasome pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109686
Abstract: In cancers, apoptosis evasion through dysregulation of pro-apoptotic and anti-apoptotic intracellular signals is a recurring event. Accordingly, selective inhibition of specific proteins represents an exciting therapeutic opportunity. Myeloid cell leukemia 1 (MCL1) is an anti-apoptotic… read more here.
Keywords: protein; sumoylation mcl1; proteasome pathway; mcl1 ... See more keywords
New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.06.013
Abstract: The gold(III)-dithiocarbamate complex AuL12 (dibromo [ethyl-N-(dithiocarboxy-kS,kS')-N-methylglycinate] gold(III)), is endowed with promising in vitro/in vivo antitumor activity and toxicological profile. Here, we report our recent strategies to improve its water solubility and stability under physiological conditions along with… read more here.
Keywords: iii dithiocarbamate; gold iii; proteasome pathway; dithiocarbamate complex ... See more keywords
The ubiquitin proteasome pathway in neuropsychiatric disorders
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2018.01.012
Abstract: The ubiquitin proteasome system (UPS) is a highly conserved pathway that tightly regulates protein turnover in cells. This process is integral to neuronal development, differentiation, and function. Several members of the UPS are disrupted in… read more here.
Keywords: proteasome pathway; pathway neuropsychiatric; neuropsychiatric disorders; ubiquitin proteasome ... See more keywords
Abstract 2689: Targeting the proteasome pathway in dactinomycin resistant Wilms tumors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2689
Abstract: Nephroblastomas or Wilms tumors are the most common pediatric renal cancer. Across all cases, the 5-year overall survival is over 90%. This is largely in part due to brute-force, chemotherapy regimens such as dactinomycin (actD)… read more here.
Keywords: targeting proteasome; wilms; dactinomycin; tumor ... See more keywords
Identification of the ubiquitin–proteasome pathway domain by hyperparameter optimization based on a 2D convolutional neural network
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.851688
Abstract: The major mechanism of proteolysis in the cytosol and nucleus is the ubiquitin–proteasome pathway (UPP). The highly controlled UPP has an effect on a wide range of cellular processes and substrates, and flaws in the… read more here.
Keywords: neural network; ubiquitin proteasome; convolutional neural; protein ... See more keywords
Targeting Ubiquitin-Proteasome Pathway by Natural Products: Novel Therapeutic Strategy for Treatment of Neurodegenerative Diseases
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.00361
Abstract: Misfolded proteins are the main common feature of neurodegenerative diseases, thereby, normal proteostasis is an important mechanism to regulate the neural survival and the central nervous system functionality. The ubiquitin-proteasome system (UPS) is a non-lysosomal… read more here.
Keywords: system; proteasome pathway; targeting ubiquitin; neurodegenerative diseases ... See more keywords
The Ubiquitin–26S Proteasome Pathway and Its Role in the Ripening of Fleshy Fruits
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032750
Abstract: The 26S proteasome is an ATP-dependent proteolytic complex in eukaryotes, which is mainly responsible for the degradation of damaged and misfolded proteins and some regulatory proteins in cells, and it is essential to maintain the… read more here.
Keywords: role ripening; 26s proteasome; pathway role; ubiquitin 26s ... See more keywords