Repetitive diacetyl vapor exposure promotes ubiquitin proteasome stress and precedes bronchiolitis obliterans pathology.
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DOI: 10.1007/s00204-021-03076-2
Abstract: Bronchiolitis obliterans (BO) is a devastating lung disease seen commonly after lung transplant, following severe respiratory tract infection or chemical inhalation exposure. Diacetyl (DA; 2,3-butanedione) is a highly reactive alpha-diketone known to cause BO when… read more here.
Keywords: bronchiolitis obliterans; proteasome stress; exposure; pathology ... See more keywords