Targeting the proteasome subunit PSMB5 by RNA interference induces proteasome dysfunction and mortality in the Colorado potato beetle (Leptinotarsa decemlineata)
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DOI: 10.1038/s41598-025-28793-x
Abstract: The Colorado potato beetle (CPB, Leptinotarsa decemlineata) is a devastating super-pest of potato crops in the northern hemisphere. Chemical control methods are expensive, harmful to non-target species, and inefficient because CPB populations can rapidly evolve… read more here.
Keywords: potato; mortality; rna; psmb5 ... See more keywords
RA190, a Proteasome Subunit ADRM1 Inhibitor, Suppresses Intrahepatic Cholangiocarcinoma by Inducing NF-KB-Mediated Cell Apoptosis
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DOI: 10.1159/000490210
Abstract: Background/Aims: Effective drug treatment for intrahepatic cholangiocarcinoma (ICC) is currently lacking. Therefore, there is an urgent need for new targets and new drugs that can prolong patient survival. Recently targeting the ubiquitin proteasome pathway has… read more here.
Keywords: proteasome subunit; subunit adrm1; intrahepatic cholangiocarcinoma; icc ... See more keywords
Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress
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DOI: 10.15252/emmm.201911861
Abstract: The ubiquitin–proteasome system degrades ubiquitin‐modified proteins to maintain protein homeostasis and to control signalling. Whole‐genome sequencing of patients with severe deafness and early‐onset cataracts as part of a neurological, sensorial and cutaneous novel syndrome identified… read more here.
Keywords: proteasome subunit; proteotoxic stress; psmc3;