Investigation of the P1′ and P2′ sites of IQF substrates and their selectivity toward 20S proteasome subunits
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DOI: 10.1515/hsz-2022-0261
Abstract: Abstract High levels of expression and activity of the 20S proteasome have been linked to many types of pathologies, including neoplasia, autoimmune disorders, neurodegenerative diseases and many more. Moreover, distinguishing between 20S proteasome catalytic subunits… read more here.
Keywords: 20s proteasome; proteasome subunits; selectivity toward; toward 20s ... See more keywords
Upregulated Proteasome Subunits in COVID-19 Patients: A Link with Hypoxemia, Lymphopenia and Inflammation
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DOI: 10.3390/biom12030442
Abstract: Severe COVID-19 disease leads to hypoxemia, inflammation and lymphopenia. Viral infection induces cellular stress and causes the activation of the innate immune response. The ubiquitin-proteasome system (UPS) is highly implicated in viral immune response regulation.… read more here.
Keywords: proteasome subunits; upregulated proteasome; covid patients; inflammation ... See more keywords
19S Proteasome Subunits as Oncogenes and Prognostic Biomarkers in FLT3-Mutated Acute Myeloid Leukemia (AML)
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DOI: 10.3390/ijms232314586
Abstract: 26S proteasome non-ATPase subunits 1 (PSMD1) and 3 (PSMD3) were recently identified as prognostic biomarkers and potential therapeutic targets in chronic myeloid leukemia (CML) and multiple solid tumors. In the present study, we analyzed the… read more here.
Keywords: myeloid leukemia; prognostic biomarkers; proteasome subunits; 19s proteasome ... See more keywords