Targeting the ubiquitin‐proteasome system in a pancreatic cancer subtype with hyperactive MYC
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12835
Abstract: The myelocytomatosis oncogene (MYC) is an important driver in a subtype of pancreatic ductal adenocarcinoma (PDAC). However, MYC remains a challenging therapeutic target; therefore, identifying druggable synthetic lethal interactions in MYC‐active PDAC may lead to… read more here.
Keywords: pdac; hyperactive myc; proteasome system; myc ... See more keywords
Inhibitors of the ubiquitin proteasome system block myofibril assembly in cardiomyocytes derived from chick embryos and human pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2022 at "Cytoskeleton"
DOI: 10.1002/cm.21697
Abstract: Details of sarcomeric protein assembly during de novo myofibril formation closely resemble myofibrillogenesis in skeletal and cardiac myocytes in birds, rodents, and zebrafish. The arrangement of proteins during myofibrillogenesis follows a three‐step process: beginning with… read more here.
Keywords: myofibril; ubiquitin proteasome; human cardiomyocytes; cardiomyocytes derived ... See more keywords
Regulation of Mammalian DNA Replication via the Ubiquitin-Proteasome System.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-10-6955-0_19
Abstract: Proper regulation of DNA replication ensures the faithful transmission of genetic material essential for optimal cellular and organismal physiology. Central to this regulation is the activity of a set of enzymes that induce or reverse… read more here.
Keywords: dna replication; proteasome system; replication; regulation ... See more keywords
The Role of the Ubiquitin Proteasome System in Glioma: Analysis Emphasizing the Main Molecular Players and Therapeutic Strategies Identified in Glioblastoma Multiforme.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02339-4
Abstract: Gliomas constitute the most frequent tumors of the brain. High-grade gliomas are characterized by a poor prognosis caused by a set of attributes making treatment difficult, such as heterogeneity and cell infiltration. Additionally, there is… read more here.
Keywords: proteasome system; role ubiquitin; system; ubiquitin proteasome ... See more keywords
Cross Talk Networks of Mammalian Target of Rapamycin Signaling With the Ubiquitin Proteasome System and Their Clinical Implications in Multiple Myeloma.
Sign Up to like & getrecommendations! Published in 2019 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2018.06.001
Abstract: Multiple myeloma (MM) is the second most common hematological malignancy and results from the clonal amplification of plasma cells. Despite recent advances in treatment, MM remains incurable with a median survival time of only 5-6years,… read more here.
Keywords: cross talk; multiple myeloma; proteasome system; biology ... See more keywords
&Dgr;9‐tetrahydrocannabinol modulates the proteasome system in the brain
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.08.026
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Cannabis is the most consumed illicit drug worldwide. Its principal psychoactive component, &Dgr;9‐tetrahydrocannabinol (THC), affects multiple brain functions, including cognitive performance, by modulating cannabinoid type‐1 (CB1) receptors. These… read more here.
Keywords: proteasome system; analysis; brain; dgr tetrahydrocannabinol ... See more keywords
Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.01.044
Abstract: Inhibitors of the ubiquitin-proteasome system (UPS) have been the object of research interests for many years because of their potential as anti-cancer agents. Research in this field is aimed at improving the specificity and safety… read more here.
Keywords: cancer; proteasome system; polyphenols ubiquitin; ubiquitin proteasome ... See more keywords
The ubiquitin-proteasome system is necessary for the replication of duck Tembusu virus
Sign Up to like & getrecommendations! Published in 2019 at "Microbial Pathogenesis"
DOI: 10.1016/j.micpath.2019.04.044
Abstract: Abstract Duck Tembusu virus (DTMUV) is a newly emerging pathogenic flavivirus that has caused massive economic losses to the duck industry in China. The cellular factors required for DTMUV replication have been poorly studied. The… read more here.
Keywords: duck tembusu; tembusu virus; proteasome system; replication ... See more keywords
Timer-based proteomic profiling of the ubiquitin-proteasome system reveals a substrate receptor of the GID ubiquitin ligase
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cell"
DOI: 10.1016/j.molcel.2021.04.018
Abstract: Summary Selective protein degradation by the ubiquitin-proteasome system (UPS) is involved in all cellular processes. However, the substrates and specificity of most UPS components are not well understood. Here we systematically characterized the UPS in… read more here.
Keywords: proteasome system; degradation; substrate receptor; ubiquitin proteasome ... See more keywords
Shaping Striated Muscles with Ubiquitin Proteasome System in Health and Disease.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2019.05.008
Abstract: For long-lived contractile cells, such as striated muscle cells, maintaining proteome integrity is a challenging task. These cells require hundreds of components that must be properly synthesized, folded, and incorporated into the basic contractile unit,… read more here.
Keywords: shaping striated; system; muscle; striated muscles ... See more keywords
Endo-lysosomal pathway and ubiquitin-proteasome system dysfunction in Alzheimer's disease pathogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.03.016
Abstract: Several lines of evidence have shown that defects in the endo-lysosomal autophagy degradation pathway and the ubiquitin-proteasome system play a role in Alzheimer's Disease (AD) pathogenesis and pathophysiology. Early pathological changes, such as marked enlargement… read more here.
Keywords: disease; pathogenesis; proteasome system; endo lysosomal ... See more keywords