iKeap1 activates Nrf2 signaling to protect myocardial cells from oxygen glucose deprivation/re-oxygenation-induced oxidative injury.
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DOI: 10.1016/j.bbrc.2021.08.024
Abstract: Nuclear factor E2-related factor 2 (Nrf2) activation could efficiently protect myocardial cells from oxygen glucose deprivation/re-oxygenation (OGDR). An ultra-large structure-based virtual screening has discovered iKeap1 as a novel, direct and potent Keap1 inhibitor. Here we… read more here.
Keywords: induced oxidative; nrf2 signaling; myocardial cells; protect myocardial ... See more keywords