Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex
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DOI: 10.1038/s41467-025-62966-6
Abstract: The BTRR (BLM/TOP3A/RMI1/RMI2) complex resolves various DNA replication and recombination intermediates to suppress genome instability. Alongside PICH, they target mitotic DNA intertwinements, known as ultrafine DNA bridges, facilitating chromosome segregation. Both BLM and PICH undergo… read more here.
Keywords: protection; centromere protection; requires strict; protection requires ... See more keywords