Vaccination with virosomally formulated recombinant CyRPA elicits protective antibodies against Plasmodium falciparum parasites in preclinical in vitro and in vivo models.
Sign Up to like & getrecommendations! Published in 2020 at "NPJ vaccines"
DOI: 10.1038/s41541-020-0158-9
Abstract: The Plasmodium falciparum (Pf) cysteine-rich protective antigen (PfCyRPA) has emerged as a promising blood-stage candidate antigen for inclusion into a broadly cross-reactive malaria vaccine. This highly conserved protein among various geographical strains plays a key… read more here.
Keywords: pfcyrpa; plasmodium falciparum; vaccination virosomally; blood ... See more keywords
Hide and seek: interplay between influenza viruses and B cells.
Sign Up to like & getrecommendations! Published in 2020 at "International immunology"
DOI: 10.1093/intimm/dxaa028
Abstract: Influenza virus constantly acquires genetic mutations/reassortment in the major surface protein, hemagglutinin (HA), resulting in the generation of strains with antigenic variations. There are, however, HA epitopes that are conserved across influenza viruses and are… read more here.
Keywords: conserved epitopes; influenza viruses; influenza; hide seek ... See more keywords
1900. Low Prevalence of Protective Antibodies to Measles Among Young Adults in Argentina
Sign Up to like & getrecommendations! Published in 2018 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofy210.1556
Abstract: Abstract Background In the last years, there has been an increase in incidence of cases of measles in high and middle-income countries. In Argentina, measles elimination was achieved in 2000, with no circulation of measles… read more here.
Keywords: antibodies measles; age; hiv; prevalence ... See more keywords
A cocktail of protective antibodies subverts the dense glycan shield of Lassa virus
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DOI: 10.1126/scitranslmed.abq0991
Abstract: Developing potent therapeutics and effective vaccines are the ultimate goals in controlling infectious diseases. Lassa virus (LASV), the causative pathogen of Lassa fever (LF), infects hundreds of thousands annually, but effective antivirals or vaccines against… read more here.
Keywords: glycan shield; lassa virus; protective antibodies; cocktail ... See more keywords
Correlation between In Vitro Neutralization Assay and Serological Tests for Protective Antibodies Detection
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DOI: 10.3390/ijms23179566
Abstract: Serological assays are useful in investigating the development of humoral immunity against SARS-CoV-2 in the context of epidemiological studies focusing on the spread of protective immunity. The plaque reduction neutralization test (PRNT) is the gold… read more here.
Keywords: correlation vitro; serological tests; neutralization; protective antibodies ... See more keywords