Immunogenicity of multi-walled carbon nanotubes functionalized with recombinant protective antigen domain 4 toward development of a nanovaccine against anthrax
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2018.07.020
Abstract: Abstract To enhance the stability and immunogenicity of protective antigen (PA) of Bacillus anthracis, Multi-walled Carbon Nanotubes (MWCNTs) as a nanocarrier, was subjected to develop a new PA domain 4 (PAD4) based nanovaccine against anthrax.… read more here.
Keywords: rpad4; protective antigen; carbon nanotubes; walled carbon ... See more keywords
Improving the stability of recombinant anthrax protective antigen vaccine.
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.09.012
Abstract: Development of recombinant protective antigen (rPA)-based anthrax vaccines has been hindered by a lack of stability of the vaccines associated with spontaneous deamidation of asparagine (Asn) residues of the rPA antigen during storage. In this… read more here.
Keywords: protective antigen; anthrax; vaccine; stability ... See more keywords
IgG-Engineered Protective Antigen for Cytosolic Delivery of Proteins into Cancer Cells
Sign Up to like & getrecommendations! Published in 2021 at "ACS Central Science"
DOI: 10.1021/acscentsci.0c01670
Abstract: Therapeutic immunotoxins composed of antibodies and bacterial toxins provide potent activity against malignant cells, but joining them with a defined covalent bond while maintaining the desired function is challenging. Here, we develop novel immunotoxins by… read more here.
Keywords: igg engineered; delivery; protective antigen; engineered protective ... See more keywords
Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-14658-6
Abstract: Following assembly, the anthrax protective antigen (PA) forms an oligomeric translocon that unfolds and translocates either its lethal factor (LF) or edema factor (EF) into the host cell. Here, we report the cryo-EM structures of… read more here.
Keywords: partially unfolded; protective antigen; anthrax toxin; edema ... See more keywords
Anthrax protective antigen is a calcium-dependent serine protease
Sign Up to like & getrecommendations! Published in 2018 at "Virulence"
DOI: 10.1080/21505594.2018.1486139
Abstract: ABSTRACT Bacillus anthracis secretes a three component exotoxin-complex, which contributes to anthrax pathogenesis. Formation of this complex starts with the binding of protective antigen (PA) to its cellular receptor. In this study, we report that… read more here.
Keywords: calcium dependent; serine protease; protective antigen; dependent serine ... See more keywords
Serum-Mediated Cleavage of Bacillus anthracis Protective Antigen Is a Two-Step Process That Involves a Serum Carboxypeptidase
Sign Up to like & getrecommendations! Published in 2018 at "mSphere"
DOI: 10.1128/msphere.00091-18
Abstract: Our findings identify a serum-mediated modification of PA20 that has not been previously described. These observations further imply that the processing of PA is more complex than currently thought. Additional study is needed to define… read more here.
Keywords: anthracis protective; bacillus anthracis; protective antigen; anthrax ... See more keywords
Recombinant full-length Bacillus Anthracis protective antigen and its 63 kDa form elicits protective response in formulation with addavax
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1075662
Abstract: Introduction Bacillus anthracis is the causative agent for the lethal disease anthrax, primarily affecting animals and humans in close contact with an infected host. The pathogenicity of B. anthracis is attributed to the secreted exotoxins… read more here.
Keywords: full length; formulation; protective antigen; addavax ... See more keywords
Asymmetric Cryo-EM Structure of Anthrax Toxin Protective Antigen Pore with Lethal Factor N-Terminal Domain
Sign Up to like & getrecommendations! Published in 2017 at "Toxins"
DOI: 10.3390/toxins9100298
Abstract: The anthrax lethal toxin consists of protective antigen (PA) and lethal factor (LF). Understanding both the PA pore formation and LF translocation through the PA pore is crucial to mitigating and perhaps preventing anthrax disease.… read more here.
Keywords: protective antigen; anthrax; toxin; structure ... See more keywords