Miconazole induces protective autophagy in bladder cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Toxicology"
DOI: 10.1002/tox.23024
Abstract: Autophagy plays a dual function in cancer progression; autophagy activation can support cancer cell survival or contribute to cell death. Miconazole, a Food and Drug Administration‐approved antifungal drug, has been implicated in oncology research recently.… read more here.
Keywords: bladder cancer; induces protective; protective autophagy; miconazole induces ... See more keywords
HSF1 upregulates ATG4B expression and enhances epirubicin-induced protective autophagy in hepatocellular carcinoma cells.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.08.039
Abstract: Considerable evidences have shown that both heat shock transcription factor 1 (HSF1) and autophagy can attenuate the sensitivity of hepatocellular carcinoma (HCC) cells to chemotherapeutic reagents. However, it is still little known whether HSF1 is… read more here.
Keywords: hepatocellular carcinoma; hsf1; hcc cells; autophagy ... See more keywords
Protective autophagy induced by physcion suppresses hepatocellular carcinoma cell metastasis by inactivating the JAK2/STAT3 Axis
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.10.064
Abstract: Aim: Although the anti‐neoplastic effects of physcion are well documented, its specific action in hepatocellular carcinoma (HCC) is not understood. Taken together, physcion is a promising drug candidate for the treatment and prevention of HCC.… read more here.
Keywords: hepatocellular carcinoma; hcc; protective autophagy; physcion ... See more keywords
CAPN2 promotes apalutamide resistance in metastatic hormone-sensitive prostate cancer by activating protective autophagy
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-024-05335-z
Abstract: Apalutamide, a novel endocrine therapy agent, has been shown to significantly improve the prognosis of patients with metastatic hormone-sensitive prostate cancer (mHSPC). However, resistance to apalutamide has also been reported, and the underlying mechanism for… read more here.
Keywords: apalutamide resistance; prostate cancer; protective autophagy; capn2 ... See more keywords
Tanshinone I induces apoptosis and protective autophagy in human glioblastoma cells via a reactive oxygen species-dependent pathway
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2020.4499
Abstract: Glioma is the most common primary malignancy of the central nervous system and is associated with high mortality rates. Despite the available treatment options including surgery, radiotherapy and chemotherapy, the median patient survival rate is… read more here.
Keywords: u87 cells; human glioma; glioma; autophagy ... See more keywords
Tumor suppressive functions of hsa-miR-34a on cell cycle, migration and protective autophagy in bladder cancer
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Oncology"
DOI: 10.3892/ijo.2023.5514
Abstract: Bladder cancer (BC) cells exhibit a high basal level of autophagy activity, which contributes to the development of a protective mechanism for cellular survival against current treatments. Hsa-microRNA-34a (miR-34a) presents anti-tumor function in several types… read more here.
Keywords: cell; protective autophagy; mir 34a; tumor ... See more keywords
CLDN6 induces chemoresistance through protective autophagy in breast cancer
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.116340
Abstract: Protective autophagy, a defensive response of cancer cells to chemotherapeutic stress, plays a critical role in the development of chemoresistance. Our previous research has demonstrated that the tight junction protein Claudin-6 (CLDN6) can induce autophagy… read more here.
Keywords: cancer; breast cancer; chemoresistance; cldn6 ... See more keywords